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Christopher M Hovens Selected Research

Selenic Acid

1/2022A phase 1b open-label study of sodium selenate as a disease-modifying treatment for possible behavioral variant frontotemporal dementia.
12/2021Sodium selenate as a disease-modifying treatment for progressive supranuclear palsy: protocol for a phase 2, randomised, double-blind, placebo-controlled trial.
1/2021Sodium selenate as a disease-modifying treatment for mild-moderate Alzheimer's disease: an open-label extension study.
11/2020A study protocol for a phase II randomised, double-blind, placebo-controlled trial of sodium selenate as a disease-modifying treatment for behavioural variant frontotemporal dementia.
1/2019Supranutritional Sodium Selenate Supplementation Delivers Selenium to the Central Nervous System: Results from a Randomized Controlled Pilot Trial in Alzheimer's Disease.
1/2016A Phase IIa Randomized Control Trial of VEL015 (Sodium Selenate) in Mild-Moderate Alzheimer's Disease.
1/2016Sodium selenate retards epileptogenesis in acquired epilepsy models reversing changes in protein phosphatase 2A and hyperphosphorylated tau.
5/2015Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury.
3/2012Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models.
8/2010Sodium selenate specifically activates PP2A phosphatase, dephosphorylates tau and reverses memory deficits in an Alzheimer's disease model.

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Christopher M Hovens Research Topics

Disease

25Prostatic Neoplasms (Prostate Cancer)
10/2022 - 06/2006
23Neoplasms (Cancer)
01/2022 - 08/2008
5Alzheimer Disease (Alzheimer's Disease)
01/2021 - 08/2010
5Neoplasm Metastasis (Metastasis)
12/2019 - 05/2011
4Margins of Excision
10/2022 - 02/2011
3Glioma (Gliomas)
01/2022 - 09/2009
3Adenocarcinoma
01/2021 - 05/2020
3Renal Cell Carcinoma (Grawitz Tumor)
05/2011 - 10/2010
2Frontotemporal Dementia (Semantic Dementia)
01/2022 - 11/2020
2Neurodegenerative Diseases (Neurodegenerative Disease)
12/2021 - 01/2016
2Obesity
05/2019 - 01/2018
2Glioblastoma (Glioblastoma Multiforme)
01/2017 - 11/2015
2Carcinoma (Carcinomatosis)
02/2016 - 06/2014
2Epilepsy (Aura)
01/2016 - 03/2012
2Traumatic Brain Injuries (Traumatic Brain Injury)
01/2016 - 05/2015
2Urinary Bladder Neoplasms (Bladder Cancer)
06/2014 - 01/2014
2Neuroblastoma
03/2012 - 08/2010
1Residual Neoplasm
10/2022
1Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome)
12/2021
1Carcinogenesis
12/2021
1Brain Neoplasms (Brain Tumor)
07/2021
1Alopecia (Baldness)
01/2021
1Inflammation (Inflammations)
05/2019
1Metabolic Syndrome (Dysmetabolic Syndrome X)
05/2019
1Disease Progression
01/2016
1Status Epilepticus (Complex Partial Status Epilepticus)
01/2016
1Post-Traumatic Epilepsy (Epilepsy, Post Traumatic)
01/2016
1Brain Injuries (Brain Injury)
05/2015
1Pancreatic Neoplasms (Pancreatic Cancer)
06/2014
1Seizures (Absence Seizure)
03/2012
1Paraneoplastic Syndromes (Paraneoplastic Syndrome)
12/2010
1Kidney Neoplasms (Kidney Cancer)
10/2010
1Meningioma (Meningiomas)
09/2010
1Tauopathies
08/2010
1Memory Disorders (Memory Loss)
08/2010
1Non-Muscle Invasive Bladder Neoplasms
07/2008
1Melanoma (Melanoma, Malignant)
12/2006

Drug/Important Bio-Agent (IBA)

11Biomarkers (Surrogate Marker)IBA
12/2021 - 08/2008
10Selenic AcidIBA
01/2022 - 08/2010
8AndrogensIBA
10/2022 - 09/2014
5Hormones (Hormone)IBA
12/2021 - 06/2006
5Androgen Receptors (Androgen Receptor)IBA
12/2021 - 11/2014
5Proteins (Proteins, Gene)FDA Link
12/2021 - 11/2012
4Biological ProductsIBA
12/2019 - 08/2008
3RNA (Ribonucleic Acid)IBA
10/2022 - 05/2016
3DNA (Deoxyribonucleic Acid)IBA
01/2022 - 01/2015
3Protein Phosphatase 2 (Protein Phosphatase 2A)IBA
01/2021 - 05/2015
3Prostate-Specific Antigen (Semenogelase)IBA
01/2018 - 02/2011
3MicroRNAs (MicroRNA)IBA
02/2016 - 01/2014
2EnzymesIBA
01/2021 - 01/2019
2Pharmaceutical PreparationsIBA
05/2015 - 03/2012
2Androstenedione (4 Androstene 3,17 dione)IBA
11/2014 - 09/2014
1erdafitinibIBA
10/2022
1mesoglycanIBA
01/2021
1AntioxidantsIBA
01/2019
1SeleniumIBA
01/2019
1Reactive Oxygen Species (Oxygen Radicals)IBA
09/2017
1Electron Transport Complex IV (Cytochrome c Oxidase)IBA
09/2017
1Mitochondrial DNA (mtDNA)IBA
09/2017
1Carboplatin (JM8)FDA LinkGeneric
01/2017
1Bevacizumab (Avastin)FDA Link
01/2017
1Kainic Acid (Kainate)IBA
01/2016
1Testosterone (Sustanon)FDA Link
11/2014
1ProgesteroneFDA LinkGeneric
11/2014
1SteroidsIBA
11/2014
1Conditioned Culture MediaIBA
11/2014
1Dehydroepiandrosterone (DHEA)IBA
11/2014
1CholesterolIBA
11/2014
1src-Family KinasesIBA
09/2014
1Messenger RNA (mRNA)IBA
09/2014
1Peptide Hydrolases (Proteases)FDA Link
09/2014
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
09/2014
1Nucleic AcidsIBA
02/2014
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
11/2012
1CateninsIBA
11/2012
1Lithium ChlorideIBA
11/2012
1Glycogen Synthase (Synthase I)IBA
11/2012
1Okadaic AcidIBA
03/2012
1Pentylenetetrazole (Metrazol)IBA
03/2012
1Drinking WaterIBA
03/2012
1MitogensIBA
10/2010
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
10/2010
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
10/2010
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
08/2010
1tau Proteins (tau Protein)IBA
08/2010
1Aurora KinasesIBA
07/2008
1benzyloxycarbonylleucyl-leucyl-leucine aldehydeIBA
12/2006
1pervanadateIBA
12/2006

Therapy/Procedure

18Therapeutics
10/2022 - 09/2009
8Prostatectomy (Retropubic Prostatectomy)
10/2022 - 02/2011
4Castration
01/2021 - 11/2014
2Neoadjuvant Therapy
12/2021 - 05/2015
1Immunotherapy
07/2021
1Withholding Treatment
01/2021
1Salvage Therapy
01/2021
1Precision Medicine
05/2020
1Transplantation
01/2019
1Operative Surgical Procedures
02/2014